User Guide

Find and interpret deep-learning-based XPO1 interactome

Exportome Atlas provides a structure-guided view of predicted XPO1-recognized signals across the human exportome.

Database and Coverage

The atlas contains approximately 4,500 XPO1-interacting or nucleocytoplasmic proteins. This focused dataset is curated from leading biological repositories:

BioGRID XPO1 interaction hits.

Human Protein Atlas Nucleocytoplasmic localization evidence.

UniProt Filtered localization annotations.

How to use the Atlas

1

Initiate a Search

Enter a protein identifier on the landing page. The atlas supports the following formats:

Example Identifiers:
O60239 TP53 SH3BP5 P04637
2

Select Your Target

Select the matching protein from the search results to open its dedicated page.
3

Analyze the Data

Review predicted NES sequences, structural scores, and binding orientations to evaluate export signal candidates.

Anatomy of a Protein Page

NES Predictions

NES sequence & score
Structural class
Binding orientation

Visualizations

Groove & NES Plots
3D structural view

Annotations

Validation status
Putative NLS locations